This could have an impact in the 2022 elections:
https://www.politico.com/news/2021/01/12/sheldon-adelson-republican-megadonor-obituary-031924His wife may continue his activities, but it is far from certain, for all that she was eventually his co-donor.
And none of his 5 children (3 he adopted who his first wife had prior to their marriage, 2 who his 2nd wife had prior to their marriage) have been visibly involved.
If Dr. Miriam Adelson does not continue down that path, the fiscal upheaval for conservative causes will be significant. Over the last decade, they've donated $480 million to Republican candidates and PACs, including $170 million in the 2020 election, nearly triple the second largest donors' offerings - $59 million by the Uihleins (Uline is their company).