Also contributes to our understanding why, if you maintain a healthy CV system, it will likely be cancer that gets you in the end. (also relates to telomere length, but that's a whole other topic) On my mom's side there's a Methuselah gene there and their CV systems are going strong in their 80s, but cancer still picks them off. Mutations build up and those cells that don't fall to apoptosis or necrosis, turn rogue.