If the Democrats get to 50 in the Senate (highly unlikely, but not impossible with a slightly bluer Georgia and and expat/military tilt for Cunningham in NC), give the leadership gavel to Warren.
If the Democrats get less than 50, say 49 or 48, offer to give the gavel to Joe Manchin for two years if enough GOPers, Murkowski and Romney come to mind as those who’d prefer to get something rather than nothing done, and might caucus around the West Virginia Senator while serving chairmanships rather than abet Mitch in further abominations as backbenchers in his continued majority.
This is where having a Lion of the Senate in the White House might come in handy.